Busy work days and extreme mental extortion have become a key reason for increased depression and stressful in the society. Depression is a feeling characterized by sadness, loss of motivation and interest, difficulty in sleeping, energy dissipation and reduced focusing. Anti depressants are taken to relieve depression till the regular drugs influence no more. In that case, a recently developed breed of anti depressants is a SNRI drug “Effexor”. Chemically called as Venlafaxine, it is a potent drug to minimize depression in the people of every age.
Its mechanism of action is to increase the level of active neurotransmitters i.e. serotonin and nor epinephrine in the synapse between the two neuronal cells of CNS. It does so by inhibiting their reuptake back into the presynaptic neuron from where it was released. Thus it is called as SNRI drug, serotonin-nor epinephrine reuptake inhibitor. It blocks the reuptake protein and increases nor epinephrine level.
It is most effective in those who have no response to all previously taken anti depressants. It is also discovered to reduce the chances of “hot-flashes” in menopausal women thus effective form them too.
The SNRI drug “Effexor” is observed to be more effective then other SSRI antidepressants. Its anti depressing effect is proved to be more than the typical antidepressant bupropion. It is considered as a remedy for treatment-resistant cases. Excessive weight loss is another effect of the drug and is currently under investigation in case of obese patients. It could relieve the unipolar depression or major depressive disorder if not successfully treated by any of the regular antidepressants.
The drug, owning to its extreme efficacy, is contraindicated in children and adolescents as it raises the chances of suicidal thoughts and self-harm. Black box warning of the medicine implies or significantly increased suicidal attempts when using the drug. Patients sensitive to any of its inactive ingredients or the Venlafaxine are not advised Effexor. Headache, nausea, insomnia, sweating, vertigo, memory loss and sexual impotence and dryness of oral cavity are its side effects. Its higher dosages may cause cardiac conduction impairments and seizures. Glaucoma characterized by increased intra-eye pressure and mild hypertension are reported as other side effects of the drug.
Due to its reduced half life, missed dose of Effexor causes immediate withdrawal symptoms in which case milder SSRI antidepressants are advised as a remedy. Serotonin syndrome characterized by hallucinations and coma due to raised serotonin level and its impaired metabolism is another disorder that the drug’s misuse could cause.
The drug is available in 25mg, 37.5mg, 50mg, 75mg and 100mg pentagon shaped peach colored capsules. Extended release versions are also available in dosage as high as 150mg for longer depression. Activated charcoal administration could prevent excessive absorption of the drug to cure overdose of the medicine. Follow the prescription as recommended by your physician. Over dosage effects of Effexor are much fatal then the usual antidepressants.
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Effexor is an antidepressant drug in the group of SNRIs (Serotonin-norepinephrine reuptake inhibitors).
